The synopsis below may give away important plot points. Oh, and Wade Wilson is now operating under an alias: Deadpool. Killing Ajax may not be as easy it seems, as Ajax is also a mutant and the meddling superhero Colossus and his sidekick Negasonic Teenage Warhead keep getting in the way. He now has two aims: find Vanessa and make Ajax pay for what he did to him. Ajax tries to keep him a prisoner but he escapes. The treatment results in Wilson getting powers of accelerated healing but also leaves him terribly disfigured. While undergoing the treatment he discovers that it will involve him becoming a mutant, and he will need to undergo several painful tests to discover what his mutant abilities are. After initially turning him down, Wilson agrees, and meets the man behind the project, Ajax. Things look bleak but a man appears who says he can be cured, through a treatment that gives him superhero powers.
Life is idyllic until one day he is diagnosed with terminal cancer.